Ibrance: Dosage, side effects, uses, and more – Medical News Today

Ibrance can interact with several other medications. It can also interact with certain supplements and foods.

Different interactions can cause different effects. For instance, some interactions can interfere with how well a drug works. Other interactions can increase side effects or make them more severe.

Ibrance and other medications

Below is a list of medications that can interact with Ibrance. This list does not contain all drugs that may interact with Ibrance.

Before taking Ibrance, talk with your doctor and pharmacist. Tell them about all prescription, over-the-counter, and other drugs you take. Also tell them about any vitamins, herbs, and supplements you use. Sharing this information can help you avoid potential interactions.

If you have questions about drug interactions that may affect you, ask your doctor or pharmacist.

Ibrance and certain antifungals

Antifungals are drugs that treat fungal infections. Taking certain antifungal drugs with Ibrance can increase the levels of Ibrance in your body. This can raise your risk of side effects from Ibrance.

Examples of antifungals that increase Ibrance levels include:

  • itraconazole (Sporanox, Onmel, Tolsura)
  • ketoconazole
  • posaconazole (Noxafil)
  • voriconazole (Vfend)

If possible, you should avoid taking these antifungals while you’re taking Ibrance. However, if you need to take one of these drugs, your doctor will likely lower your dosage of Ibrance for a period of time.

Ibrance and certain antibiotics

Antibiotics are drugs that treat bacterial infections. Taking certain antibiotics with Ibrance can increase the levels of Ibrance in your body. This can increase your risk of getting side effects from Ibrance.

Examples of antibiotics that can increase Ibrance levels include:

  • clarithromycin
  • telithromycin (Ketek)

If possible, you should avoid taking these antibiotics while you’re taking Ibrance. However, if you have to take one of these antibiotics, your doctor will temporarily lower your dose of Ibrance.

Ibrance and drugs for HIV infection

If you take Ibrance with certain HIV medications, you are more at risk of getting side effects from Ibrance. This is because some HIV drugs can increase the levels of Ibrance in your body.

Examples of HIV drugs that increase Ibrance levels include:

  • atazanavir (Reyataz)
  • cobicistat (Tybost)
  • darunavir (Prezista)
  • fosamprenavir (Lexiva)
  • indinavir (Crixivan)
  • lopinavir/ritonavir (Kaletra)
  • nelfinavir (Viracept)
  • ritonavir (Norvir)
  • saquinavir (Invirase)

If possible, you should avoid taking Ibrance if you’re taking one of these HIV drugs. However, if you have to take them, your doctor will prescribe you a low dosage of Ibrance.

Ibrance and certain drugs for tuberculosis

Taking Ibrance with certain treatments for tuberculosis can lower the levels of Ibrance in your body. This could make Ibrance less effective. You should avoid taking Ibrance with any of these drugs.

Examples of these drugs include:

  • rifabutin (Mycobutin)
  • rifampin (Rifadin)
  • rifapentine (Priftin)

Ibrance and certain drugs for seizures

Taking Ibrance with certain seizure medications can lower the levels of Ibrance in your body. This could make Ibrance less effective. You should avoid taking Ibrance with any of these drugs.

Examples of these drugs include:

  • carbamazepine (Carbatrol, Equetro, Tegretol)
  • fosphenytoin (Cerebyx)
  • oxcarbazepine (Trileptal)
  • phenobarbital
  • phenytoin (Dilantin, Phenytek)
  • primidone (Mysoline)

Ibrance and certain heart medications

Taking Ibrance with certain heart medications may increase the levels of the heart medication in your body. This could raise your risk of side effects from the heart medication. Your doctor may need to lower your dosage of the heart medication to avoid this interaction.

Examples of heart drugs that could be affected by Ibrance include:

  • pimozide (Orap)
  • quinidine (Cin-Quin, Cardioquin, Quinact, Duraquin)

Ibrance and certain immunosuppressants

Immunosuppressant drugs reduce the activity of your immune system. Taking certain immunosuppressant drugs with Ibrance may increase the levels of those drugs in your body. This could raise your risk of side effects from the immunosuppressant.

Your doctor may need to lower your dose of the immunosuppressant to avoid this interaction. Examples of immunosuppressants that could be affected by Ibrance include:

  • cyclosporine (Neoral, Gengraf, Sandimmune, Restasis)
  • everolimus (Afinitor, Zortress)
  • sirolimus (Rapamune)
  • tacrolimus (Prograf, Astagraf XL)

Ibrance and certain drugs for migraine

Taking Ibrance with certain migraine medications may increase the levels of the migraine medication in your body. This could raise your risk of side effects from the migraine drug. Your doctor may need to lower your dose of the migraine medication to avoid this interaction.

Examples of migraine drugs that could be affected by Ibrance include:

  • dihydroergotamine (DHE-45, Migranal)
  • ergotamine (Ergomar)
  • ergotamine and caffeine (Cafergot, Migergot, Wigraine)

Ibrance and certain strong pain relievers

Taking Ibrance with fentanyl (Duragesic, Subsys, Lazanda, Abstral, others) or alfentanil (Alfenta, which is used as anesthesia during surgery) may increase the levels of these strong pain relievers in your body. This could raise your risk of side effects from the pain relievers.

To avoid this interaction, your doctor will lower your dosage of fentanyl or alfentanil.

Ibrance and herbs and supplements

Always check with your doctor or pharmacist before using any herbs or supplements with Ibrance.

Ibrance and turmeric

It’s not known for sure whether turmeric interacts with Ibrance. However, some research suggests that turmeric may change the way that Ibrance is broken down in your body. This may lead to higher levels of Ibrance in your body and increase your risk of side effects.

Talk with your doctor first if you want to take turmeric while taking Ibrance.

Ibrance and St. John’s wort

Don’t take St. John’s wort (also called Hypericum perforatum) while you’re taking Ibrance. This herbal remedy can lower the levels of Ibrance in your body and make it less effective.

Ibrance and foods

Don’t drink grapefruit juice or eat grapefruit while you’re taking Ibrance. Grapefruit can increase your risk of side effects from Ibrance by making it build up in your body.

Source: https://www.medicalnewstoday.com/articles/326656

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